RIU 435 Lecture 9: Fetal Neural Axis pt 2
2 Dec 2020
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Document Summary
Corpus callosum is fibrous tract that connects the cerebral hemispheres. Dysgenesis of corpus callosum describes range of complete to partial absence of callosal fibers that cross the midline. Begins to develop at 12 weeks gestation. May be associated with other cns malformations. May be transmitted in autosomal- dominant or autosomal- recessive manner. Multiple syndromes have been associated including include trisomies 21, 13, 18,11, 8 and triploidy. Aicardi, apert, opitz, joubert syndromes infections, alcohol abuse. Prognosis depends on high incidence of associated anomalies; many carry poor prognosis. May be asymptomatic or associated with mental retardation and/ or seizures. Widely separated lateral ventricular frontal horns with medial indentation of medial walls. Dilated occipital horns (colpocephaly), giving lateral ventricles teardrop shape. Results from obstruction, atresia, or stenosis of aqueduct of. Aqueduct of sylvius connects third and fourth ventricles. Cranial masses and ventricular hemorrhage also contributing factors of acquired obstruction. Primary aqueductal stenosis usually x-linked and has autosomal recessive inheritance.
