NURS 2060 Lecture 6: Anemias Objectives
Document Summary
Briefly describe the role of the cellular components in the plasma. Describe the factors involved in the iron cycle: iron binding: hemoglobin and myoglobin (o2 binding protein in the muscle cells, iron storage: ferritin and hemosiderin (mainly intracellular inside the tissues, iron sources (23mg needed daily for erythropoiesis) Aids in absorption of iron in the gut. (cid:315) hepcidin = release of stored iron & an (cid:313) in dietary iron absorption. Outline erythropoiesis and its regulation: erythrocytes, kidneys: lack of o2 (hypoxia) = (cid:313) in erythropoietin production (stimulates bm for synthesis of rbcs, bone marrow: increases in response to erythropoietin. That creates inactive fibrinogen into activated fibrin which leads to the blood clot: important components of hemostasis. Coagulation system: hageman factor (factor xii), tissue factor (tissue thromboplastin), fibrinogen/fibrin, prothrombin/thrombin, and calcium. The ultimate step is conversion of fibrinogen into fibrin: tissue factor release can occur secondary to:
