BIOL 4570 Lecture Notes - Lecture 21: Mhc Class Ii, Cell Adhesion Molecule, Smallpox Vaccine
Document Summary
Immune memory is long term and not caused by chronic restimulation. In absence of continual restimulation, we see rapid immune response. Immunological memory persists and can be reactivated in absence of long term pathogen. Protective once you have had disease, you can be protected against disease throughout life. After smallpox vaccination, antibody levels show no significant decline, and t cell memory shows half life of 8 to 15 years. Primary response: start with low affinities somatic hypermutation begins to start in primary response. Secondary response: way more memory b cells that recognize same pathogens produce iga (respiraotyr viruses, mucosal infections) and igg way higher affinity due to undergoing somatic hypermutation and selection. Quantity and quality of b cell responses change. After 3rd or 4th time, you don"t get significant increases. Those with best affinity will be selected for and will proliferate. Na ve t cells always try to hone receptors to lymph nodes.
