BIOL 121 Lecture Notes - Lecture 30: Bone Marrow Failure, Hematopoietic Stem Cell, Erythropoietin
Document Summary
Rbcs are produced in the bone marrow. Rbcs are destroyed in the liver and spleen (short life, 120 days) After hemoglobin is produced during differentiation, rbcs lose nucleus and other organelles. Some iron stored as ferritin (backup reserve of iron) Transferrin carries iron from recycled rbc to bone marrow (recycles iron) Folic acid (pregnant women- important in cell division) Vitamin b12 (necessary for folic acid function) To increase epo, decrease amount of o2 intake (working out at high elevation stimulates synthesis of red blood cells) A decrease in the total number of rbcs and/or a decrease in the concentration of hemoglobin per rbc. All blood cells descended from a pluripotent hematopoietic stem cell (cell that can become any type of cell involved with cardiovascular system) When vessel is damaged, exposure of blood to subendothelial tissue (collagen) leads to 3 responses. Platelets bind to exposed collagen, leading to platelet activation. This leads to release of chemical mediators (thromboxane)
