BIOL 120 Lecture Notes - Lecture 9: Thyroid Peroxidase, Thyroid, Pendrin
Document Summary
Gland is really made up 3d spheres, that are lined by a single layer of cells called follicular cells. Induced by tsh which is induced by trh. Don"t make up the lining of the follicle. Capillary that is releasing tsh which is binding to receptors on the basal side of the cell and stimulating the cell, tsh also binds to and activates iodide pumps (sodium iodine transporters, symporters). Iodide then comes into the blood cell, then an enzyme called thyroid peroxidase. The enzyme will oxidize iodide into iodine and then put iodine onto thyroidglobulin (concept is called iodinating). The transport of iodide into the apical surface of the cell is called pendrin transporter. Thyroglobulin becomes iodinated so now we can endocytosis and lysosomes will cut up so the thyroglobulin so that t3 and t4 will be released. T3 and t4 binds to tbg, transthyretin or albumin. Decreased levels in t3 and t4, less negative feedback.
