BIOL 115 Lecture Notes - Lecture 19: Severe Combined Immunodeficiency, Infectious Mononucleosis, Fibrin
Document Summary
Severe combined immunodeficiency disease (scid) an inherited disease in which lymphocytes don"t develop. Leukemia a group of cancers in which wbcs proliferate without control. Most of these wbcs are abnormal, so don"t function well. Infectious mononucleosis the epstein-barr virus (ebv) infects lymphocytes, resulting in fatigue, sore throat, and swollen lymph nodes. Result from fragmentation of large cells called megakaryocytes in the red bone marrow. About 200 billion platelets are made per day. Plasma proteins prothrombin and fibrinogen are also involved in blood clotting. Vitamin k is necessary for the formation of prothrombin. Is important so that plasma and formed elements don"t leak out of broken vessels. 13 different clotting factors, calcium ions, and enzymes participate in clot formation. When a vessel breaks, platelets clump to partially seal it. Platelets and injured tissues release a clotting factor called prothrombin activator, which converts prothrombin to thrombin. Thrombin acts as an enzyme that converts the plasma protein fibrinogen to fibrin.
