PSB-2000 Lecture Notes - Lecture 13: Substantia Nigra, Basal Ganglia, Mptp
Document Summary
In the kindling model there is similarities and differences: similarities: convulsions similar to those in epilepsy and the phenomenon resembles post tbi epileptogenesis, differences: in epilepsy seizures are spontaneous, but in the model they are solicited. Cortex excites basal ganglia which then inhibits the thalamus and then the thalamus typically excites the cortex. If there is too much inhibition going towards the thalamus, then the cortex is stimulated less. Loss of substantia nigra which provides dopamine to other structures. Presence of lewi bodies around the body. Proteins cause the cause the cells in that are to degenerate. Symptoms: slowness and rigidity of movement, resting tremor, changes in gate, masklike face. There is no single risk and there is many risk factors. Accidently produced in synthesis of mppp (synthetic heroin) People who took this had ended up with severe parkinson"s overnight. They did this model with animals to see what happens and how can they treat it.
