PCB 4674 Lecture Notes - Lecture 12: Zygosity, Allele Frequency, Genotype Frequency
29 Oct 2016
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Self fertilization: in every generation, # heterozygotes is halved. Each homozygote increases by half that # Allele frequencies do not change: empirical data. Because inbreeding results in predictable increases in homozygosity it can be used to detect inbreeding in populations. Investigated sea otters that went through a bottleneck in the late 1800s: genotyped 33 otters, collected at random, 16 ss (0. 485), 7 sf (0. 212), 10 ff (0. 303, allele (f) ~ 0. 6 s, 0. 4 f. Deviations from hw: important to note that different influences can have similar effects on hw predictions, e. g. homozygosity = heterozygosity. Anything that causes an allele to move towards either 0 or fixation leads to a loss of heterozygosity. Selection for homozygotes or against heterozygotes lethal alleles, founder effects, drift in small pops or when selection is neutral or weak (or both) inbreeding: exactly what is going on usually involves additional research. Well of course we can, why else would i ask: coefficient of inbreeding, f.
