PCB 4594 Lecture Notes - Lecture 1: Zone Of Polarizing Activity, Blastema, Polydactyly
What happens if an extra ZPA is grafted?
Duplication of structures
What are Hox genes important for?
Patterning in limb
Perturbations in Shh signaling can cause what?
Polydactyly (extra digits)
Name 4 model organisms commonly used in regeneration research
Planaria (flatworms)
Crickets & Axoloti (Salamander)
Goldfish & Mice
Morphallaxis
New cell division occurs
Re-patterning of existing tissue
Epimorphosis
Growth of completely new patterned structures
Ex: Limb regrowth
Blastema
Regeneration bud
-undifferentiated proliferating cells
What kind of signaling is important for establishing polarity (direction) of regeneration?
Wnt/ B-Catenin
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