PSYC 210 Lecture Notes - Lecture 9: Social Skills, Brain Structure And Function, Antipsychotic

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Schizophrenia is a devastating disorder that is characterized by profound disruptions in all domains of
normal human functioning - cognitive, emotional, motivational, and social
Hallmark characteristic is PSYCHOSIS: significant loss of contact with reality
It is not dissociative identity disorder (aka: multiple personality syndrome)
Psychosis is not Psychopathy - psychopathy is not a DSM diagnosis but it is closely related to antisocial
personality disorder
Psychosis is when people lose touch with reality
Epidemiology:
Prevalence for 12 month period - 1 in 100, lifetime prevalence - 1%
Costs associated with schizophrenia is ~ $60 billion/year - chronic and impairing and reduces overall
production in a country
Age on onset: late teens, early 20s -- use resources for a good 15 years
Sex differences: More frequent in men, age of onset is earlier in men, symptoms more severe in men
Suicide rates are very high - 12x more likely to die of suicide
Symptoms:
Positive Symptoms - things that shouldn't be there, but are (~50-70% patients) - delusions,
hallucinations
oDelusions - distinct from hallucinations such as erroneous beliefs about self, world,
people. They are fixed and insensitive to contradictory evidence and typical psychotic
delusions are:
Delusions of grandeur - messages from Jesus Christ or I am jesus christ
Delusions of persecution - CIA is out to get me
Delusions of control - I am controlling your thoughts with my laptop
Delusions of reference - song on the radio is a special message from jesus christ
Thought blocking/insertion - thoughts have been removed or added that aren't
theirs
oHallucinations - some sensory stimulus in the absence of the actual stimulus. Can occur
in all sensory domains but auditory ones are the most common such as voices that are very
intrusive (criticizing and command) and can make patients do harmful and violent acts in
order to obey the voices.
Negative Symptoms - things that should be there, but are not (~25% patients) - loss of interest,
motivation
oAvolition - inability to get involved in daily activities - sit on the couch and watch tv, cant
do little things like hygiene related
oAlogia - absence of speech, difficulty in communicating - very one word answers, no
elaboration or interest
oAnhedonia - absence of pleasure in normally pleasurable activities
Consummatory pleasure - pleasure experienced by achieving something
Anticipatory pleasure - pleasure experienced by the anticipation of something
--- deficit in SCZ
oAffective flattening/Blunted Affect - lack of outward expressed emotions - modulation
of tone, facial expression, they experience it just as deeply as other but do not show it
outwardly
oAsociality - lack of interest in social interaction
Disorganization: also known as formal thought disorder
oDisorganized speech: incoherence, "word salad"
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Document Summary

Schizophrenia is a devastating disorder that is characterized by profound disruptions in all domains of normal human functioning - cognitive, emotional, motivational, and social. Hallmark characteristic is psychosis: significant loss of contact with reality. It is not dissociative identity disorder (aka: multiple personality syndrome) Psychosis is not psychopathy - psychopathy is not a dsm diagnosis but it is closely related to antisocial personality disorder. Psychosis is when people lose touch with reality. Prevalence for 12 month period - 1 in 100, lifetime prevalence - 1% Costs associated with schizophrenia is ~ billion/year - chronic and impairing and reduces overall production in a country. Age on onset: late teens, early 20s -- use resources for a good 15 years. Sex differences: more frequent in men, age of onset is earlier in men, symptoms more severe in men. Suicide rates are very high - 12x more likely to die of suicide.

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