BIOL 141 Lecture Notes - Lecture 5: Dehydration Reaction, Phosphodiester Bond, X-Ray

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Purines and pyrimidines are the nitrogen-containing bases found in the nucleotides that make up dna and rna. Purines have two rings in their structure, while pyrimidines have just one. G -- c makes three bonds together (more stable) A -- t (u) makes two bonds together. Nucleotide - the building blocks of nucleic acids. Contain a phosphate group, a sugar, and a nitrogenous base. The phosphate group is bonded to the 5" carbon sugar - essential for linkage. The oh (hydroxyl) group on the phosphate group and the 3" carbon of the sugar form a bond. Condensation or dehydration synthesis - h2o is a waste product of this linkage. This is important because these continuous linkages create the (negatively charged) sugar phosphate backbone for rna and dna. Polymerization reactions are typically endergonic (absorb energy) requiring energy input. Activated nucleotides are charged nucleotides used for energy (unique to each nucleotide)

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