BIOL 141 Lecture Notes - Lecture 26: Covalent Bond, Cytosol, Pyruvate Dehydrogenase

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Goal is for carbons to get more oxidized. Nadh requires a greater change in free energy to be reduced from. 2c come in as aceytl coa, 2c leave as co2. Product of entire pathway (atp) does feedback inhibition. Indication of high energy in cell: atp, nadh, fadh2. Indication of low energy in cell: nad+, amp/adp, fad. Are cofactors, but are needed to phosphorylate things, so they are also like substrates. Regulated by looking at concentrations of the molecules. Feedback inhibition: occurs when an enzyme in a pathway is inhibited by the product of that pathway of that pathway. Product feeds back to inhibit an earlier enzyme to turn off synthesis. Enzyme can transfer a phosphate group to another molecule to another. Pyruvate processing and krebs cycle within mitochondrial matrix, within cristae. Folds in mitochondria increase surface area for transmembrane proteins. On the inner membrane are proteins needed for the electron transport chain and the protein that carries out oxidative phosphorylation.

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