BIOLOGY 3 Lecture Notes - Lecture 30: East Los Angeles College, Renal Glucose Reabsorption, Diuresis
Document Summary
Open device allows direct vascularization of the patient"s blood vessels into the device that holds the transformed hescs. Pros: hesc cells are nourished and oxygenated and like a real pancreas are in close contact with blood vessels for both faster response and better sensing of blood sugar levels. Cons: the host immune system has access to the hesc cells and since they have a different hla complement than the host they could be attacked. A semi-permeable membrane allows for diffusion of molecules across the membrane but prevents the patient"s blood vessels from coming in contact with the transformed hescs. Pros: the host immune system does not have access to the hesc cells and even though they have a different hla complement than the host they could not be attacked. Cons: since the nutrients and oxygen of the blood have to diffuse across the membrane it is more difficult to support the hesc cells.
