PSYCH-101 Lecture Notes - Lecture 9: Opioid Use Disorder, Nucleus Accumbens, Opiate
18 Sep 2020
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Document Summary
More pure than in the past increase likelihood of overdose. Stimulate receptors of the body"s opioid system. Cramps, sweating/chills, increase in hr and bp, insomnia and vomiting. Half death of people with heroin dependence by suicide, homicide or accident. Exposure to infectious diseases via shared needles. Subcortical, which is evidence that dependence develops w/o conscious recognition. Liking- pleasure obtained by taking the drug. Dopamine system becomes sensitive to the drug and the cues associated with drug. Sensitivity to cues induces and strengthens wanting. Ecstasy mimics serotonin, makes cell start to export serotonin, resulting in overstimulation of cell"s serotonin receptors. Cannabis same as heroin, except with cannabinoid instead of opiate receptors. Methamphetamine mimics dopamine forces dopamine out of cell, which overstimulates cell"s dopamine receptors. Alcohol binds with glutamate and gaba receptors, causing sedative effects. Cocaine blocks dopamine transporter, causes overstimulation of cell"s dopamine receptors. Lsd mimics serotonin, unlike ecstasy can bind in ways to cause inhibitory and/or excitatory effects.
