BIOSC-139 Lecture Notes - Lecture 22: Globin, Thrombopoietin, Growth Factor
27 Oct 2020
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Document Summary
Stages of blood cell formation myeloid stem cells progenitor cells (colony-forming units) Can no longer divide to reproduce themselves. Will differentiate to form specific cell types (eg. cfu-e rbcs) Hemopoietic growth factors (regulate differentiation, growth of progenitor cells): Some are involved in stimulating blood cell production. Colony-stimulating factor (csf), interleukin stimulate wbc production. Reverse rbc production in end-stage kidney disease (epo) Stimulate wbc formation in cancer patients with bone marrow destruction (csf) Flexible increase in surface area/volume ratio lifespan about 120 days. 2 million new rbcs enter circulation every second. 1/3 of rbc weight is (oxygen-carrying protein that gives red color to blood) Red blood cells don"t use the oxygen that they are carrying because they do not have organelles. Each heme contains an iron ion (fe2+) that can combine reversibly with one oxygen molecule. Each hemoglobin molecule can carry four o2 molecules from lungs to tissue cells. Hb transports 23% of total from cells to lungs.
