HSCI 301 Lecture Notes - Lecture 14: Measles Vaccine, Fluconazole, Complications Of Pregnancy
23 Mar 2017
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Document Summary
Antimicrobial therapy is selective in toxicity (can kill invading microorganism without harming host cells: need to know: Isotretinoin (accutane: measles vaccine, varicella vaccine, rubella vaccine, small pox vaccine. Antibacterial drugs: penicillins, cephalosporin, tetracyclines, aminoglycosides, marcrolides, flouroquinolones, others. Microorganisms: has a large spectrum of activity: gram (+) cocci, gran (+) bacilli, gram (-) cocci, gram (-) rods, anaerobic organisms, spirochetes, mycoplasma, chlamydia, other. Spectrums of activity: narrow spectrum: only acts on limited group of organisms, extended spectrum: works on all gram (+) and some gram (-) organisms, broad spectrum: effects a ton of different kinds of microorganism. Drug resistance: happens when the max level of an antibiotic no longer halts bacterial growth. Some are just intrinsically resistant, but some acquire resistance from other organisms. Acquired resistance mechanisms: decreased penetration of antibiotic: rejection at the membrane, modification of target sites, decreased accumulation of antibiotic, they can establish efflux pumps to push antibiotic out of cell, enzymatic inactivation of the antibiotic.
