HSCI 301 Lecture Notes - Lecture 17: Bone Marrow Suppression, Misoprostol, Ondansetron
23 Mar 2017
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Dna & rna synthesis depends on purines (adenine & guanine) and pyrimidines (cytosine, thymine, & uracil: nucleobase: nitrogen-containing compounds in nucleosides & nucleotides used to make dna & rna. Neoplasm (tumor): abnormal mass of tissue from neoplasia. Neoplasia: abnormal proliferation of cells: be(cid:374)ig(cid:374) (cid:374)eoplasia: ca(cid:374)cer cells that do(cid:374)"t spread, malignant neoplasia: cancer cells that do spread, invade neighboring tissues, enter blood vessels, and metastasize to different sites. Combination therapy = better than one therapy in most cancers: uses (cid:373)ultiple moa"s, affects lots of differe(cid:374)t ki(cid:374)ds of cells, & delays resistance/relapse. Antibiotics/antracyclines: moa: inhibits rna & dna synthesis by inserting itself in the rna/dna strands and also inhibits topoisomerase 2 (enzyme needed for dna transcription, drugs, doxorubicin, daunorubicin. Alkylating agents: moa: attaches to alkyl group in dna and makes dna strands unable to separate/uncoil = no more cell division, drugs, cyclophosphomide (cytoxin) Ifosfamide (ifex: adverse effects of bone marrow depression, anorexia, nausea, vomiting, diarrhea, and on germ cells.
