BIOL 031 Lecture Notes - Lecture 7: Distal Convoluted Tubule, Renal Artery, Mesonephric Duct
22 Dec 2020
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Document Summary
Human physiology histological features of the renal corpuscle, filtration membrane of the glomerulus, and the juxtaglomerular apparatus; indicate the functional significance of the structure of these components. Renal corpuscle - the beginning of the nephron. Limit = albumin), fenestrated capillary epithelium, and a shared basal lamina which is the main barrier. Key role in regulating blood pressure by activation of the renin- angiotensin-aldosterone system. Located where the renal tube of the nephron returns to connect to the renal corpuscle at the vascular pole. Composed of the macula densa and juxtaglomerular cells. Macula densa - consists of modified thick ascending limb cells that stain darker and more crowded nuclei. Juxtaglomerular cells are acted upon by the macula densa and secrete renin that causes aldosterone to act on the dct and cts to reabsorb salt and water from the urine. They also act on afferent arterioles to control blood flow and hence filtration rate.
