BIOL 030 Lecture Notes - Lecture 26: Buffy Coat, Vasospasm, Mercury Poisoning
17 Sep 2020
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Complex mixture of water, proteins, nutrients, electrolytes, nitrogenous wastes, hormones, and gases. Leukopenia: low white blood cell count (10000/ul) # rbcs, # wbcs, platelets and relative #s of wbcs. Cancer of hemopoietic tissues abnormally high number of circulating leukocytes. Platelets play an important role in all three. Platelet contains a complex internal structure and an open canalicular system. Secrete vasoconstrictors that help reduce blood loss. Stick together to form platelet plugs to seal small breaks. Secrete procoagulants or clotting factors to promote clotting. Chemically attract neutrophils and monocytes to sites of inflammation. Secrete growth factors that stimulate mitosis to repair blood vessels. Thrombopoiesis stem cells (that develop receptors for thrombopoietin) become megakaryoblasts. Megakaryoblasts repeatedly replicate dna without dividing. Megakaryocytes live in bone marrow adjacent to blood sinusoids. Form gigantic cells called megakaryocytes with a multilobed nucleus. 100 m in diameter, remains in bone marrow.
