BIOL 030 Lecture Notes - Lecture 26: Cytoplasm, Granulopoiesis, Myelocyte
16 Sep 2020
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Band 3 ion transporter & site for ankyrin to hold onto. Spectrin + band 4. 1 + actin lets rbc be pliable. Identifiable because they have a thin band of ribosomes. Hereditary spherocytosis abnormal spectrin causes rbc shape deformity. Sickle cell disease valine substituted for glutamate. Can have reverisibly and non-reversibly sickled rbcs. T-lymphocytes cell mediated immunity, many made as children and live forever immune memory, 90% in blood. B-lymphocytes 4-10% in blood, mediate humoral immunity. Hyalomere outer visible ring containing microtubules allowing it to be contractile. Granulomere internal structure of platelet (no nucleus) Surface-opening tubule where granules are released. Dense tubular system machinery of platelets. Cytoplasm of megakaryocytes just buds off and platelets are formed. Coagulation disorders can be caused by vitamin k deficiency, hemophilia. Can be caused by leukemia, cancer, chemo drugs. Can result in petichiae (little bruises) and ecchymoses (big hemorrhages) All granulocytic leukocytes have azurophilic granules which are part of the lysosome and are clear.
