BIOL 030 Lecture Notes - Lecture 10: Tyrosinase, Basal-Cell Carcinoma, Keratinocyte
16 Sep 2020
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Artifact - actually looks clear at lm level because it doesn t have desmosomes and shrinks. Different races have same number of melanocytes just have different # of melanin granules. Melanin only pigment produced by skin. Carotene yellow exogenous plant pigment deposited in stratum corneum and adipose. Melanin epidermal unit melanocyte and associated keratinocytes (keratinocytes that have melanin made by that melanocyte) Located in the stratum basale and spinosum. Tyrosinase converts tyrosine melanin in melanocyte vesicles. Premelanosomes small vesicles containing a little bit of melanin. Melanosomes more developed with more melanin. Melanosome complex forms after keratinocyte and melanin granules fuse with lysosomes. Produce more melanin, 2. have longer lasting melanosome complexes, 3. have granules in all layers. Uvb 370 nm (long, this gets in farther) Causes sunburn induces inflammation of blood vessels in dermis. Tanning darkening of melanin with exposure to sunlight and increased tyrosinase activity over several days of continued exposure.
