NS 1150 Lecture Notes - Lecture 37: Naloxone, Acupuncture, Dynorphin
2 Dec 2016
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Document Summary
Alternative healing=hippocrates: eating wholesome food is the basis for good health. Leave your drugs in the chemist"s pot if you can heal the patient with food . However, things are still caused by pathologies: acupuncture, homeopathy. Take a little poison, body will react and overcome that poison: aromatherapy, hypnotherapy, massage therapy. Human touch is relaxing: spiritual therapy. Someone comes in with full garb, inject with you to potentiate placebo. Optimizing placebo effect: man hooked up to infusion pump. Infusion of saline or naloxone: opioid neurotransmitters. Higher affinity for opioid receptors than neurotransmitters themselves. Experiment: saline placebo worked on it, naloxone blocked the effect of the placebo. Chemical changes do occur if you believe in placebo. Sensory input pain perception opiate receptor: expectation release endogenous opiates. But if used naloxone ceases to have analgesic effect. Conditions affected by placebo and blocked by pharmacological antagonists: pain, parkinson, depression. Problems with inferring causality from clinical observations: clinical fallacy.
