NS 1150 Lecture Notes - Lecture 20: Meal Replacement, Sympathetic Nervous System, Genetic Correlation
1 Nov 2016
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Evidence against a biological theory of eating. No feedback from fat has been identified. Biological signals are not specific for eating behavior. Alternative explanation for vmh lesion induced hyperphagia. When you destroy vmh -> release inhibition -> surge of insulin -> animal stays in the hyper-insulin state -> cause substrates to go in tissue, come out of any storage depot -> makes you hungry. Alternative explanation for vmh stimulation induced anorexia. Alternative explanation for lh lesion induced anorexia. Small yearly energetic error does not mean there is a physiological regulation. Food deprivation does not necessarily cause overeating. If an animal is given a liquid diet, anorexia is ameliorated. Animals constantly press bar which activates the lh lesion. U end up doing some crazy shit. 25% of increase in weight in is muscle. Large mass requires more energy to move. No evidence that deprivation of food will cause you to eat more. Overfeeding does not affect your baseline intake.
