FGSS 2140 Lecture Notes - Lecture 6: Sex Steroid, Leydig Cell, Delta 4
14 Sep 2016
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Lecture #6 readings: chapter 4 (male: review. 2. two pathways (delta 4 and delta 5), where cholesterol is the precursor that gets converted eventually into testosterone then estriol or estradiol (know the basic pathways) Steroidogenic pathway not all steroid producing cells have the enzymes to go through the whole pathway of sex steroid production. Evidence that lh stimulates testis to make testosterone. Evidence that leydig (interstitial) cells make testosterone: effects of testosterone (what are target tissues?) 1. sex accessory glands and structures: male secondary sex characteristics. 4. cardiovascular system (?) general metabolism (androgens are anabolic) 2. especially on muscle and bone nitrogen amino acids. 5. specific behaviors in animals (humans: mood, aggression. 1. hypo. acts on pituitary to decrease lh secretion (sensitivity to gnrh), hy- pothalamus decrease gnrh. 1. diffuses into seminiferous tubules: androgen transport, metabolism, and mode of action, transport. 1. via blood, bound to testosterone blinding globulin (tbg)
