BIOMG 1350 Lecture Notes - Lecture 21: Methyltransferase, Chromatin, Symmetry In Biology
16 Nov 2016
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Document Summary
Sequential exceptions: some gap genes regulate other gap genes and segment polarity genes, egg polarity pair rule. Dissecting the regulatory region of the pair rule gene eve: 7 different regulatory segments. Insert stripe 2 regulatory segment in reporter fusion dna for lac z. Lac z shows up in stripe 2. Within stripe 2: 40 nucleotide pairs, has multiple binding sites for: transcriptional repressors. Bicoid and hunchback: competitive binding sites to certain binding sites, presence of repressors and/or activators depend on region in which stripe is in. Maintaining memory after cellularization: syncytial blastoderm=egg polarity, gap, pair-rule. Transient gene expression: cellular blastoderm=segment polarity genes. How is segment identity specified: these genes specify the number, siz, spacing and polarity of segments but not info about segment identity (leg or wing) Homeotic mutations: homeosis=transformation of one body part for another. Homeotic selector genes in drosophila: bithorax.
