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BIOMG 1350 Lecture 15: Vesicular Transport

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fuchsiadog160
5 Oct 2016
School
Cornell University
Department
Molecular Biology and Genetics
Course
BIOMG 1350
Professor
Huffaker

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Document Summary

Transport vesicles transport between organelles of endomembrane system: provides routes of communication between interior of cell and surroundings, proteins and lipids, er to plasma membrane, plasma membrane to lysosomes. Transport vesicles carry soluble proteins and membrane between compartments: secretory pathway. Er golgi side branch through endosomes to lysosomes: endocytic pathway. Responsible for ingestion and degradation of extracellular molecules. Removes material from plasma membrane: through endosomes lysosomes, each transport vesicle carries a specific proteins to appropriate destination. Depends on proteins displayed on surface of transport vesicle. Vesicle budding is driven by the assembly of a protein coat: coated vesicles. Distinctive protein coat on vesicles that bud from membranes. Allows for direct interaction with membrane it will fuse with. Captures molecules for onward transport: clathrin. Plasma membrane on inward: each vesicle starts off as clathrin coated pit. Assembles as ring around neck of each deep coated pit.

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Related Questions

Which compartments are involved in vesicular transport? How are transport vesicles formed and targeted appropriately? What proteins are involved and what are their roles? What kinds of modifications are added to proteins in the ER? What determines whether a protein stays in the ER or moves on? Be sure to understand how vesicles fuse with their target membranes, and the consequences of fusion for the vesicle’s cargo as well as the proteins and lipids that are in the membrane. Know the structure of the Golgi apparatus and its role in intracellular trafficking. Understand the secretory process, endocytosis, exocytosis, function of the endosomes, and function of the lysosomes. Understand why endocytosis happens and how it can be regulated to take up specific molecules.

True or False: Native, fully folded proteins that are synthesized in the cytosol are imported into peroxisomes without unfolding.

Fill in the blank

According to Molecular Biology of the Cell, the ["retrieval", "endocytic", "secretory"] pathway leads outward from the ER toward the Golgi apparatus and cell surface, with a side route leading to lysosomes, while the ["retrieval", "endocytic", "secretory"] pathway leads inward from the plasma membrane. In each case, ["endocytic", "retrieval", "secretory" ] pathways balance the flow of membrane between compartments in the opposite direction, bringing membrane and selected proteins back to the compartment of origin.

29 Most proteins destined to enter the endoplasmic reticulum _________.

(a) are transported across the membrane after their synthesis is complete.

(b) are synthesized on free ribosomes in the cytosol.

(c) begin to cross the membrane while still being synthesized.

(d) are keep binding to Signal recognition particle (SRP) while they are translated.

30 Which of the following choices reflects the appropriate order of locations through which a protein destined for the plasma membrane travels?

(a) lysosome → endosome → plasma membrane

(b) ER → lysosome → plasma membrane

(c) Golgi → lysosome → plasma membrane

(d) ER → Golgi → plasma membrane

31 Which of the following statements about vesicle budding from the Golgi is false?

(a) COPII can initiate vesicle budding on Golgi membrane.

(b) Some vesicles budded from Golgi membranes move towards ER.

(c) Once vesicle budding completed, clathrin molecules are released from the vesicle.

(d) Clathrin molecules act at the cytosolic surface of the Golgi membrane.

32 Which of the following statements is false?

(a) The signal sequences on mitochondrial proteins are first bound to translocator on outer membrane after translation.

(b) Most mitochondrial proteins are not imported from the cytosol but are synthesized inside the mitochondria.

(c) Chaperone proteins in the mitochondria facilitate the movement of proteins across the outer and inner mitochondrial membranes.

(d) Mitochondrial proteins cross the membrane in their unfolded state.