SOCR 330 Lecture Notes - Cardiovascular Disease, Hemangiosarcoma, Bone Tumor
Document Summary
Any one genotype equally likely to pair with any other genotype in population. Mating pair more closely related than two individuals drawn at random from population. Increased probability of homozygosity for deleterious alleles (inbreeding depression) Probability that offspring from first cousin mating has two copies of single allele identical by descent is 1/16. Detecting inbreeding as a deviation from hardy-weinberg equilibrium. Two alleles with incomplete dominance control flower color. Geneticist counts 100 plants and finds 12 white-colored ones. Next year counts 100 plants again and finds 19 pink-flowered ones. The breeding coefficient f measures the intensity of inbreeding in a population. F can be calculated as the reduction in heterozygotes in a population (2pq h ) 2pq = expected number of heterozygotes (from hardy-weinberg) Inbreeding does not affect allele frequencies in gene pool. Inbreeding may help remove deleterious alleles from population gene pool ( purging the genetic load ) Inbred individuals homozygous for deleterious alleles will suffer reduced fitness.
