MIP 342 Lecture Notes - Tradd, Cd28, Chromatin
11 Jul 2014
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Carma, which leads to activation of nf b; ras activates the map kinase cascade, which activates fos, a component of the ap-1 transcription factor the transcription factors nf b, Nfat, and ap-1 act to induce specific gene transcription, leading to cell proliferation and differentiation. Lat adaptor protein, is phosphorylated, phosphorylates g protein. With these transcription factors, il-2 gene is produced. B-cell signaling is similar to cd4/cd8/cd3, cd21/cd19/cd81; also help propagate a signal when antigen binds to the bcr. Kinases happen plc- cleaves phosphatidylinositol bisphosphate (pip2) to yield diacylglycerol (dag) and inositol trisphosphate (ip3) Dag and ca2+ activate protein kinase c protein kinase c activates a transcription factor, nf b. Small g proteins activate map kinase cascades the ras-induced kinase cascade induces and activates fos, a component of the ap-1 transcription factor. Ip3 increases intracellular ca2+ concentration, activating a phosphatase, calcineurin calcineurin activates a transcription factor, nfat (nuclear factor of activated t cells)
