LIFE 210 Lecture Notes - Colorectal Cancer, Amyloid Precursor Protein Secretase, Glycosylation
Document Summary
Signaling between adjacent cells via notch and delta regulates cell fate choices. Latent regulation: cells signal their neighbors to become a certain cell type. Processing and activation of notch by proteolytic cleavage. Notch undergoes 3 successive changes, the last 2 triggered by delta binding. The cytosolic fragment translocates to the nucleus activation of transcription. Wnts are secreted proteins that act as local mediators involved in development. No wnt signaling -catenin is degraded in proteasomes. Binding of wnt to its cell surface receptor no -catenin degradation it migrates to the nucleus, and activates transcription cell proliferates. Cubitus interruptus (ci) is normally cleaved transcriptional repressor. Hedgehog binding to surface receptor no ci cleavage trascrip activation. Excessive hedgehog signaling can lead to cancer: skin basal cell carncinoma. Mediates many stressful, inflammatory, and innate immunity responses. Excessive signaling can cause chronic inflammation and cancer. Nf b is normally inhibited by i b degraded upon activation nf b translocates to the nucleus.
