BMS 460 Lecture Notes - Tryptophan, Thiazide, Oncotic Pressure
26 Apr 2014
School
Department
Course
Professor
Document Summary
Inflammation of the liver that usually results from exposure to certain chemicals and drugs, e. g. , industrial chemicals, acetaminophen. Hepatotoxicity accounts for 27% of the drugs withdrawn from the market since. Acetaminophen is the leading cause of acute liver failure. Hepatic cellular necrosis, scarring, kupffer cell hyperplasia, and infiltration by mononuclear phagocytes occur with varying severity. Alcohol, anoxia, and pre-existing liver disease worsen the effects of some toxins. Direct effects may result from increasing fluidity of biological membranes and thereby disrupting cellular function. Indirect effects are in part a consequence of its metabolism. Because of increased fatty acid synthesis (from glucose available after reaching. Disorganizes the lipid portion of cell membranes, leading to adaptive changes in their composition. Alters the capacity of liver cells to cope with environmental toxins. Oxidation of ethanol produces acetaldehyde, a toxic and reactive intermediate. Body uses 3 different enzymes to convert alcohol to acetaldehyde. All 3 work by stripping two h+ atoms off the alcohol molecule.
