BMS 420 Lecture Notes - Pharmacogenomics, Ossification, Aspirin

• School: CSU
• Department: Biomedical Science
• Course: BMS 420
• Professor: Charles Miller

Document Summary

Can provide continued circulation of blood flow if one of the main vessels is disrupted. Interruption of blood flow in carotid arteries with preserved vertebral supply may result in severe coma, although not necessarily death. Dependent upon contractile (metabolism) activity of muscle cells. Low capillary recruitment at rest (25%); might be 100% in exercise. High tone at rest related to sympathetic nervous vasoconstriction input. Arterial baroreceptors influence sympathetic nervous input to vascular smooth muscle cells of skeletal muscle. Huge muscle mass and vascularity has significant role in maintenance of arterial blood pressure levels. At rest: sympathetic nervous system determines tone whereas in active contraction, local metabolic factors predominate. Two types of resistance vessels: arterioles and arteriovenous anastomoses. Av anastomoses: finger tips, toes, soles of feet, palms of hand, lips, ears and nose (muscular walls with richly supplied sympathetic nerves) do not respond to metabolic vasodilators and with intense sns, lumen may become obliterated.