GEN-3000 Lecture Notes - Lecture 2: Robertsonian Translocation, Nondisjunction, Chromosomal Translocation
20 Oct 2017
School
Department
Course
Professor
Document Summary
Males are haploid (single set of chromosomes: males develop from unfertilized eggs. 1/2000 female births; 45, x: missing a chromosome, develop into females, klinefelter syndrome, males, small testes, breast enlargement, reduced facial/pubic hair, one or more y chromosomes, multiple x chromosomes (can be xxxy, xxxxy or. Xxyy: often sterile, may have mild cognitive impairment, 1/500 male births often undiagnosed; 47, xxy, poly-x females- triplo-x syndrome (xxx) - tall, thin, sometimes normal fertility, normal intelligence, 1/1000 female births. Development: all hu(cid:373)a(cid:374)s ha(cid:448)e (cid:862)(cid:374)eutral(cid:863) (cid:894)u(cid:374)differe(cid:374)tiated (cid:895) go(cid:374)ads earl(cid:455) i(cid:374) de(cid:448)elop(cid:373)e(cid:374)t. If testes develop, they secrete testosterone (triggers male character development) and. Burkitt lymphoma: break may occur in a gene ix. If mistake is made in attempting to fix the chromosome instead of risking losing the whole dna strand xi. Translocations in meiosis- in diploid organism dna was damaged, attempted to fix and ended up with translocation xii.
