BIOL-2230 Lecture Notes - Lecture 3: Diabetes Mellitus Type 1, Immunogenicity, Mhc Class I

• School: Clemson University
• Department: Biology
• Course: BIOL-2230
• Professor: Cummings

Document Summary

Immune systems: nonspecific immune system, anything foreign will be attacked (innate immunity, specific immune system. Individual cells (lymphocytes: b and t (lots of each of those types, specific for what they attack (adaptive, there has to be recognition. It"s a fu(cid:374)(cid:272)tio(cid:374)al syste(cid:373), (cid:374)ot a(cid:374) orga(cid:374) syste(cid:373) Identify the nonspecific defenses, both superficial and internal. Isolates pathogen, encounters and then eliminates: antimicrobial proteins (cid:894)either atta(cid:272)k a(cid:374)d kill, or i(cid:374)terrupt orga(cid:374)is(cid:373)"s a(cid:271)ility to reproduce) Interferon: cell infected by a virus will secrete interferon protects the neighboring cells, does not stop attacks from occurring to those cells, but disables the virus from being able to replicate, complement system: Phagocytic mechanism: phago(cid:272)yte re(cid:272)og(cid:374)izes pathoge(cid:374)"s (cid:272)ar(cid:271)ohydrate surfa(cid:272)e (cid:373)arkers, enhanced via opsonization, opsonization: process of marking something for destruction, cytoplasmic extensions adhere to pathogen, pathogen pulled inside cell in vacuole, called phagosome. Lysosome binds with phagosome forming phagolysosome: lysosome + phagosome=phagolysosome.