CAS PS 337 Lecture Notes - Lecture 4: Henry Molaison, Temporal Lobe, Viral Encephalitis
7 Aug 2018
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Department
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Professor
9/12/13
PS 337 - #4
Reading for Exam #1:
❖ Corkin Article “What’s New with patient HM?”*** READ
o Work with patient HM, written a long time ago
o Professor at MIT
o Goes through tasks we talk about
❖ Corkin “H.M.’s medial temporal lobe lesion”
o Optional read, good review of the anatomy
❖ Squire “the legacy of patient HM”*** READ
o Tired to know exactly what is the hippo responsible for
o A more recent paper that is a good read
o Update of HM after he had died
❖ Rosenbaum/Tulving Article “The case of K.C.”*
o Don’t spend too much time reading this
o Another skimming article
❖ O’Kane, Kensinger, Corkin “Evidence for semantic learning in... Patient HM”*
READ
o There is a controversy here, weather amnestic patients can learn new
semantic info
o Is there evidence for semantic learning in amnesic patients
o She said to kind of skim this to learn more about experiments
❖ Mans/Squire *
o Just reading thinking about if there’s evidence for amnesic patients
❖ Stefanacii/Squire*** READ
o Paper about patient EP that will reinforce the same information we already
know
o Look into what’s different between EP and HM even though they have
similar damage
o Goes over the procedures we talked about in class.
Etiology of Disease that lead to episodic memory deficits
❖ Anoxia (preferentially damaging HPC) = loss of oxygen to the brain
o Leaves MTL cortical structures intact, but the hippocampus is damaged
bilaterally
❖ Lesion (with damage to MTL)
o Like patient HM who had the surgery
o Unilateral lesion to MTL is used to treat epilepsy, but the BI-lateral
damage to HM was unique.
❖ Head Trauma (extent of damage?)
o This occurred to patient KC (motorcycle accident)
❖ Viral encephalitis (damaging MTL)
Document Summary
Corkin article what"s new with patient hm? *** read: work with patient hm, written a long time ago, professor at mit, goes through tasks we talk about. Corkin h. m. "s medial temporal lobe lesion : optional read, good review of the anatomy. Squire the legacy of patient hm *** read: tired to know exactly what is the hippo responsible for, a more recent paper that is a good read, update of hm after he had died. Rosenbaum/tulving article the case of k. c. : don"t spend too much time reading this, another skimming article. O"kane, kensinger, corkin evidence for semantic learning in Read: there is a controversy here, weather amnestic patients can learn new semantic info, is there evidence for semantic learning in amnesic patients, she said to kind of skim this to learn more about experiments. Etiology of disease that lead to episodic memory deficits.
