CAS NE 525 Lecture Notes - Lecture 1: Basal Ganglia, Prefrontal Cortex, Excitotoxicity
10 Aug 2018
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Document Summary
Parkinsons, ms, als, huntingtons, prions, alzheimers, ftd, down. All diseases except for ms have familial cases. Helps understand disease, proteins found to be mutated in familial disease can sometimes be the ones that affect sporadic cases. Pet label for l-dopa in pd to see how many functional dopaminergic neurons are left that would take it up. Common features and molecular pathways in neurodegenerative diseases loss of function or gain of toxic function of certain proteins. Irreversible neuronal death: neurons are post-mitotic cells, do not undergo cell division after maturing into neurons: when neuron degenerates, astrocytes are swollen, creates post-ischemic lesion (lack of blood flow, lack of oxygen, inappropriate metabolic activities, cell death) No treatment that can revert the disease. Must find a drug that is not symptomatic, one that halts progression, reverses it, or prevents it. Seem to occur in the elderly (alzheimer"s parkinson"s) or earlier (20-30) for. Methods of diagnosis: advantages and disadvantages: diagnosis for all need to.
