CAS BI 315 Lecture Notes - Lecture 9: Transmembrane Protein, Membrane Potential, Resting Potential
6 Feb 2020
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Document Summary
Membrane proteins allow for selective solutes across membrane transmembrane protein allow free diffusion channel gating. 10h channels selectively alter membrane permeability to specific ions. 2 main classes ungated dg always open leak channels kt voltage gated changes in vm. The kt concentration gradient is barely affected by movement of kt ions. Equilibriumpotential predicts hypothetical vm of a cell when only focal ion is moving. 70mv membrane"s not only permeable to kt and electrochemical gradient is very different movement of all. Goldman hodgkin katz ghk equationpredpictsrelative um t p ci tin t p ci tout. Um 61 log pnacnat out in ions contributes to restingpotential t pk k"tont in. Pk kt pna nat membrane potential bounded by equilibriumpotentials of nat and kt. If pnas than pia or pa then dominates ghk equation umenatequilibrium resting potential generated by a different concentration gradients of ions usually nat and kt permeability. Action potentials are rapid transient changes in membrane potential.
