CAS BI 211 Lecture Notes - Lecture 16: Bone Marrow, Pernicious Anemia, Buffy Coat

• School: Boston University
• Department: Biology
• Course: CAS BI 211
• Professor: Elizabeth Co

Document Summary

A little less than half of blood is rbc (hematocrit, red liquid) White middle is buffy coat, wbc and platelets. Plasma: 90% water usually, but varies throughout day (ex: coffee makes it less, plas(cid:373)a protei(cid:374)s: (cid:272)a(cid:374)"t lea(cid:448)e (cid:271)lood (cid:448)ia (cid:272)apillar(cid:455) (cid:271)(cid:272) too large, pri(cid:373)ar(cid:455) os(cid:373)oti(cid:272) regulators of blood. If (cid:449)e did(cid:374)"t ha(cid:448)e the(cid:373), there (cid:449)ould (cid:271)e (cid:374)o os(cid:373)oti(cid:272) gradie(cid:374)t a(cid:374)d we would lose even more of our plasma volume into tissue due to hydrostatic pressure (if low on plasma proteins, lower bp and edema) Made by liver, we see these symptoms in liver failure. Rbcs (cid:272)a(cid:374)"t repli(cid:272)ate (cid:271)(cid:272) (cid:374)o (cid:374)u(cid:272)leus, so the(cid:455) (cid:272)a(cid:374) o(cid:374)l(cid:455) (cid:272)o(cid:373)e fro(cid:373) (cid:271)o(cid:374)e (cid:373)arro(cid:449) We are constantly recycling rbcs and replensishing them, not just when we have blood loss: around four months, kid(cid:374)e(cid:455)s (cid:449)ill dete(cid:272)t (cid:449)hi(cid:272)h rbcs are(cid:374)"t (cid:272)arr(cid:455)i(cid:374)g e(cid:374)ough o2, release hormone (erythropoietin) to call for new distribution of rbcs. They become smaller when they mature, which is important because capillaries are very small.