CAS BI 203 Lecture Notes - Lecture 12: Microrna, Stem-Loop, Ribosomal Rna
18 Jan 2020
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Central dogma so of gnenneasa transcription rna translation protein. Humangenome has 20 ooo 25 ooogenes and all cells containthesegenes why are there functional and structural differences then. In each cell only a subset of the 20 25 ooo genesisexpressed. Somegenes are expressed in many corall cell types lex tubulin. Somegenes are expressed only in particular cell types. Rnatranscript c. e ie nen. es genomicpromoter gene ona iss regulation of expression oftranscription is critical. A fundamentals of transcription in prokaryotes i rnapolymerase the principle enzymeresponsible for rnasynthesis a in e coli 5 subunits dczcopies. b. bg or core polymerase polymerase activity. Like dnapot rnapot synthesizesrna in 5 c unlike dnapot rnapot can initiate de novo d howdoesrnapoi know where tosynthesize rna. Rnapot is directed to the beginning of genes via interactions with genepromoters. 1 promoters a region of dna upstreamof the tss where rnapoi binds to initiatetranscription upstream anything 5 of dna downstream anything 3 of dna e howdoesrnapol know to bind to promoter.
