CAS BI 107 Lecture Notes - Lecture 6: Heterozygote Advantage, Sickle-Cell Disease, Cummington, Massachusetts
4 Nov 2016
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Office hours: 5 cummington street room 423 mwf 4-5pm. Heterozygote favored in the case of the nigerian malaria case. Best fitness given value of 1: area without malaria, as and aa both 1, area with malaria: 1 for as and 0. 9 for aa. In africa the incidence of the s allele is 0. 12 = q. Therefore p = 0. 88 (1. 0 0. 12 = 0. 88) p2 = 0. 774 proportion of aa individuals q2 = 0. 014 proportion of ss individuals. 2pq = 2 x 0. 88 x 0. 12 = 0. 211- as individuals. Only 1 in 375 americans of african descent develop sickle cell anemia (ss individuals). If the population is in h-w equilibrium then o o o q = square root of 0. 00267 = 0. 052 p = 1. 000 0. 052 = 0. 948. 2pq = 0. 099; q2 = . 00267; p2 = 0. 8989. In a certain population of people 36% of the population is born with sickle cell (homozygous recessive individuals).
