PSYC 3300 Lecture Notes - Lecture 15: Endocannabinoid System, Frontal Lobe, Phencyclidine
Document Summary
In the cns it produces alertness and faster responsiveness: some cns neurons that release dopamine contain these receptors so it also elevates mood. Caffeine: alertness, and decreased sleepiness, withdrawal includes headaches, fatigue, shakiness, and craving, produces arousal increased. Increases the release of dopamine and acetylcholine: blocks adenosine receptors (adenosine antagonist, adenosine has sedative and depressive effects, blocking adenosine receptors leads to wakefulness. Psychedelics: primarily work of serotonin receptors, cause distortions of perception, hallucinations, visual, auditory, temporal, self. Increased mood: lsd (lysergic acid diethylamide, psilocybin-mushrooms, drugs are structurally similar to serotonin (serotonin agonist, ecstasy, similar in structure to amphetamine. Increase energy, sociability, sexual arousal: stimulates both dopamine and serotonin release agonists, higher doses produce hallucinations, can destroy serotonergic neurons, pcp (phencyclidine) Increases inhibition of a subtype of glutamate receptor (antagonist) Inhibits uptake of serotonin: marijuana, bind with cannabinoid receptors found on axon terminals, thc (delta 9-tetrahydrocannabinol, phytocannobinoid, endocannabinoid, released by post-synaptic neurons, acts as retrograde messengers, regulate presynaptic nt release.
