PB HLTH 162A Lecture Notes - Lecture 10: Myxoma Virus, African Meningitis Belt, Siderophore
29 Dec 2019
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Document Summary
Epidemiologic triad: disease causation dependent on microbe, host, environment. Ie- dif breeds of sheep w/dif genetic resistance, dif environ. Host virulence (capacity of pathogen, compared to others , to produce disease; depends on microbe & host factors) Can increase w/passage in host or decrease/attenuate by sub-culture (=vaccines, test by passage on another species) pathogenesis (method by which pathogen produces disease ) Traits that allow it to invade (exo/endo-toxins, colonization, adhesion, etc. ) Biological: vectors in/sources of food, water, air, soil. Co-evolution of host & microbe (above) microbe virulence/pathogenesis. Ex: myxoma virus kills rabbits (strains of moderate virulence prevailed- best for infecting; rabbits had less deaths over time) Virus develops in continue to infect host. Level of virulence depends on relationship to transmission & its effect on virus" ability to persist & reproduce ; ie- host death, symptoms, behavior, etc) Factors: dose, entry-adherence (fimbriae), colonization & infection (nutrients, battle for iron / host remove transferrin, bac use siderophores.
