PB HLTH 162A Lecture Notes - Lecture 8: Mycobacterium Tuberculosis, Dendritic Cell, Helminths
Document Summary
Regulation of the immune response and pathogen specificity. Antibody isotypes are localized in di erent parts of the body. Can di erentiate into di erent into di ere3nt cell types that can have di erent functions. Important in defense against intracellular bacteria bec it activates macrophages. Dendritic cells sense it > activates naive cd4 t cells > di erentiation into th1 t cells. Defense against extracellular pathogens such as helminth infection. If there"s worm infection, one of the immune responses is to increase mucous production. Causes th17 di erentiation for neutrophil recruitment, which then make nets to control the fungal infection. Fungal pathogen can be dimorphic (yeast or hypoform) Macrophages are having a hard time controlling yeast form bec its too big for phagocytosis. *** immune response can be specialized with the type of pathogen you"re infected with. There is a threshold level of antigen to activate immune response.
