NUSCTX 103 Lecture Notes - Lecture 19: Programmed Cell Death, Ribonucleotide Reductase, Gpx4

• School: Berkeley
• Department: Nutritional Sciences And Toxicology
• Course: NUSCTX 103
• Professor: Sul

Document Summary

Lecture #19: iron: a reactive electron acceptor and donor, a trace element, useful chemical properties, forms bonds with electronegative elements. Iron readily accepts and donates electrons: ferric ion (3+) or ferrous (2+) Iron is essential to many biological processes: oxygen transport and retention, dna synthesis, ribonucleotide reductase, which catalyzes reduction of ribonucleotides to deoxyribonucleotides, contains fe, electron transport, fe-s proteins in the electron transport chain. Iron: a reactive electron acceptor and donor: redox cycling between ferrous (ii) and ferric (iii) can generate highly reactive oxygen species, hydroxyl radicals can damage virtually all types of macromolecules: lipids, carbs, nucleic acids, and amino acids. Biologichemical strategy to overcome iron toxicity: biolochamical strategy to prevent toxicity, constrain iron reactivity through association with proteins or prosthetic groups, heme containing protein bound to oxygen. Iron-sulfur clusters, organization of iron is really well established: ferritin iron storage in cellular components, all of these prevent fenton"s reaction but still allows iron to be used for.