MCELLBI 104 Lecture Notes - Lecture 23: Recombination Hotspot, Myc, Base Pair
8 Apr 2016
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Link all genotypes with phenotypes (diseases: snps associated with complex traits in humans, genotyped list of odds ratio, disease risk, know what the data means. On same haplotype group: mutation is constant force, it"s always entering new snp in population, never expect to see genome behave simply, have snps arise that aren"t in ld. Slide 22: nonrandom association b/w 2 loci = linked = linkage disequilibrium, pure ld, never observe 2 of the possible genome haplotypes. Slide 25: recombination in humans, primary sequence of bases, recombination is not random, not between every gene, see how haplotype structure differs in population, no shades of grey, either absolute or 0 ld. Just b/c find tagsnps that are causative, doesn"t mean it"s that snp that causes it. Slide 33: 8q24: myc gene (cell cycle regulation, finds a snp at 8q24, enhancer of myc gene that responds to wingless gene (hedgehog, common mutation in cancer??)
