BIOL-242 Lecture Notes - Lecture 64: Sertoli Cell, Spermatogenesis, Chapter 27
16 Jun 2020
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Chapter 27 part 6 | sustentocytes, hormonal regulation of male reproductive function, & mechanism of. Extend through wall of tubule and surround developing cells. Provide nutrients and signals to dividing cells. Secrete testicular fluid into lumen for sperm transport. Phagocytize faulty germ cells and excess cytoplasm. Tight junctions divide tubule into two compartments. Adluminal compartment meiotically active cells and tubule lumen. Prevents sperm antigens from escaping into blood activation of immune system. Important - sperm not formed until puberty, absent during immune system development, would not be recognized as "self" Takes 64 72 days if conditions hospitable. Pressure of testicular fluid pushes immotile sperm into epididymis motility and fertilizing power. Gradual decline in male fertility past 50 years. Environmental toxins, pvcs, phthalates, pesticides, herbicides, compounds with estrogenic effects, antibiotics, radiation, lead, marijuana. Also, lack of selenium, excessive alcohol, lack of specific ca2+ channel, anatomical obstructions, hormonal imbalances, oxidative stress, fevers, hot tubs.
