NSC 3356 Lecture Notes - Lecture 6: Fluoxetine, Catechol-O-Methyl Transferase, Melanin
26 Feb 2017
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Catecholamines and 5-ht: although they share the same synthesis pathway the difference come from that the neurons lack the enzymes to make the other. Due to epi the effect lasts for a very long time. Lots of mao in liver to get rid of it: to protect us from possible hypertension crisis etc sudafed. Th then aadc (or dopa-decarboxylase) for da :not everyone has exactly the same so these enzymes exist in families called isozimes so these enzymes have their own number. Tetrahydrobiopterin is readily available (typically saturated) it has to be recycled in the citric acid cycle. Change the affinity so like increase it for tetrahydrobiopterin rate is the same if you decrease it slows. Arousal and that we don"t miss stimuli for survival so think about what happens if there is too less (dp) and too much (impulsive) Look at their function in the brain: da, a9, a10.
