BIOL 3000 Lecture Notes - Lecture 4: Phosphodiester Bond, Pyrimidine, Deoxyribose
1 Feb 2017
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Francis crick grad student at cambridge; worked with x-ray diffraction. Rosalind franklin (cid:449)orked at ki(cid:374)g"s (cid:272)ollege; used (cid:454)-ray diffraction to obtain pictures of the dna molecule. Through her blueprint of dna discovered the double helix of dna. Using chemical info. obtained by chargaff and the physical data of franklin helped develop the idea of the helical form of dna. Watso(cid:374) a(cid:374)d cri(cid:272)k"s (cid:373)odel of the heli(cid:272)al stru(cid:272)ture of dna (cid:449)o(cid:374) the(cid:373) the 1962 nobel prize. Outside of dna has strong negative charge because of large amount of phosphorous. Information storage large amount due to the 4 bases. *different forms are hypothesized to have different biological functions structure and function. Polarity free groups, (cid:1007)" oh a(cid:374)d (cid:1009)" po(cid:1008) If dsdna molecule has 10% g how much t is present: g=10% c=10%= 20, 100%-20%=80%/2, 40%=a 40%=t, given the following is the molecule ds or ss, a=18% t=26% c=26% g=30, sum of purine=sum of pyrimidine if double stranded.
