BIOL 430 Lecture Notes - Lecture 10: Peripheral Neuropathy, Kinesin, Protein Isoform
Document Summary
Bipolar sensory; mostly in pns and retina. Multipolar motor (efferent) and interneurons; cns and pns; nearly all cells in the cns are multipolar think about function of different designs. To make an axon neuronal growth cones: Elaborate branching architecture during neuronal development requires actin- based motility and guidance cues, encountered in the environment in order to form an axon. Microtubules part of cytoskeletal system that start in soma; whole distance of that. Filopodia - beginning of development; revert to this design when we damage a axon neuron. Reconnect - go back and forma new growth cone. Picking up these proteins of acting bundles ; rearrange and keep moving. Cell adhesion molecules (cams): integral membrane proteins mediating adhesion between growing axons and eliciting intracellular signalling within the growth cone. Cams are the major class of proteins mediating correct axonal navigation of axons growing on axons (fasciculation). Cams (belonging to the immunoglobulin superfamily) and cadherins (ca- dependent cams).
