BIOL 300 Lecture Notes - Lecture 24: Citric Acid Cycle, Enzyme Inhibitor, Phosphofructokinase
Document Summary
Examine efficiency and flexibility of the pathway in the face of cellular demands for atp and changes in the food supply. Every nadh gives 3 atp and every fadh2 gives 2 atp. 2 atp + 2 nadh = 2+6= 8 atp. 6 nadh + 2 fadh + 2 atp= 18+4+2= 24 atp. We know atp yields about 7 kcal/mol and let"s say glucose gives a net of 32 atp this is. Glucose has 686 kcal/mol and 224/686= 32% This may not seem a lot but it is not bad since fuel in cars only gives 25% of the energy. If there is too much of a substance the product will inhibit the enzyme. For example if there is too much atp produced then the atp will inhibit phosphofructokinase. Nadh and citrate from the citric acid cycle can also inhibit that enzyme. Once there is a need of the enzyme the inhibition stops. Carbs, fats, and proteins all enter this process.
