CORE-107 Lecture Notes - Lecture 4: Pierre Deniker, Antihistamine, Typical Antipsychotic
8 Jan 2019
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Document Summary
Psychopharmacology has been criticized as leading to the importance of psychological and social factors being neglected when considering the causation of psychiatric illness and an overemphasis on medication to the detriment of psychosocial treatments. The 1950s had new medication enter into psychiatric practice. Chlorpromazine was the first antipsychotic and was followed by a large number of other antipsychotics, many with diverse chemical structures. Chlorpromazine was synthesized in 1950 by the french pharmaceutical company, but was not originally planned to be a psychiatric drug. The company was developing antihistaminergic drugs for use in a range of conditions including nausea and allergies. Chlorpromazine was first used as an anesthetic for surgery in 1951, but was soon after used in psychiatric patients for the same purpose and it was discovered that chlorpromazine had antipsychotic properties/effects. Two psychiatrists, jean delay and pierre deniker, working at st anne"s hospital in paris used chlorpromazine to treat in patients, including people suffering with mania and schizophrenia.
